106 22nd Ave SE is a truly one of a kind estate. Situated on a nearly triple lot in a NON FLOOD ZONE, this 8 bed plus a third story loft, 5 and a half bath property includes a studio apartment above the garageperfect for guests, rental income, or multigenerational living. Renovated by the Lender family (of Lender Bagels fame, with included signed artwork by Jay Lender of SpongeBob and Hey Arnold), this property blends artistic charm with extensive modern upgrades. Constructed like a fortress with concrete poured pilings ensuring complete peace of mind. The ground floor features 3 bedrooms and 2.5 baths, including a luxurious primary suite with private yard access, dual walk in closets, a wet bar, and a steam shower system. Upstairs you'll find 4 additional bedrooms, 2 bathrooms, and a private balcony overlooking the pool. The above garage apartment includes a full bath, kitchenette, W/D hookups, mini split, and tongue and groove ceiling. Outdoor amenities include a HUGE pool, a jacuzzi, an outdoor shower, gazebo, tiki hut, brand new landscaping and fencing, RV and boat parking, and custom decking ideal for an outdoor kitchen, yoga platform, or lounge area. Some of the upgrades include a newer roof (2022), newer mini splits (2022), newer HVAC (2019), brand new fencing (2025), brand new landscaping (2025), PGT impact rated windows, skylights, and doors, all new plumbing, all new wiring, custom Cuban tile and hardwood floors, surround sound speaker systems, crown molding, custom built in bookcases and closet systems in every room, luxury lighting, and so much more. The dining area dazzles with vaulted ceilings, exposed beams, and skylights. The chefs kitchen is outfitted with a gas range, newer appliances, custom pull out cabinetry and built ins. Just blocks from Lassing Park and minutes to downtown St. Pete, this exceptional home offers space, flexibility, and craftsmanship rarely seen. Move in ready and truly irreplaceable. Call today for a private showing of one of the most unique estates in all of Tampa Bay!